My boots keep going red and become unusable

My boots keep going red and become unusable unless I take them off and put them back on. It’s not necessarily game breaking but it is more than mildly irritating to have to do that every instance. I do not have the same type of rune double up at all in my boots either.

Most likely this is an attribute issue, something is making you not have the required attributes to equip the item, though usually once something is equipped it is fine if no other gear is changing so I'm not 100% sure that is the issue.

Are you using a weapon swap with attributes on one of your sets but not the other?