Which chaos trial modifiers are the most and the least dangerous for you?

For my glass cannon build, I consider almost free these:
- more rare monsters (more farm)
- stronger bosses (one shot them anyway)
- reduced defense (don't have any)
- reduced mana/hp recovery (can feel it only at level 2, need to use mana potion sometimes then)
- monsters can't be stunned or slowed
- buffs expires 3 times faster
- monsters slow on hit (I don't got hit much)
- stormcaller runes (barely notice them even at level 3, very easy to avoid)

And I am trying always avoid these:
- +50% damage after 50 sec (completing level where you need survive couple of minutes much harder with this)
- turrets (too many projectile, can't avoid all of them)
- Petrifying statues (on some level quite hard to avoid)
- no flask charges (without life regen, I need them)
- 50% less area of effect and projectile speed (doesn't work for my build)
- Monsters release deadly volatiles on death (just hate those things)

Everything else I consider as annoying and dangerous if there will be too much of annoying modifiers but playable.

Statues.

Same as Sekhema : nerfs to Damage / Resistance is a big nope , the rest can be worked around ( vines , traps , ... ) .