Allocating Chaos Inoculation causes you to be considered on low mana at all times.

Taking the Chaos Inoculation keystone causes you to be considered on low mana, regardless of your actual mana total. This is easily noticeable with the notable Mental Toughness, which should apply a 15% reduced mana cost when not on low mana- if Chaos Inoculation is taken, this cost reduction stops applying, even if you are at full mana.

This is very similar to a recently hotfixed bug that caused you to be incorrectly considered on Low Life with Chaos Inoculation allocated. But with mana, instead of life.

+1 Mental Toughness worked normally with CI previously, was changed with 0.1.0e Hotfix 6