Manaburn reduces your maximum mana

Every 30 stacks of manaburn reduces your maximum mana by 1.
this reduction is mana is unrecoverable while you have manaburn stacks.

Reserving or reducing your maximum mana enough, and you won't be able to keep your tinctures up, even if you have the mana recovery and skill cost reduction.


PS:
manaburn also has a minimum burn of 1, meaning if you reduce your maximum mana to less than 100, it won't impact manaburn any more (unsure if bug or intended).